Lev el of c reactive protein (CRP) among cardiovascular disease patients with chronic periodontitis in Cardiovascular Department of Dr. Soetomo National Hospital Surabaya

Abstract

Background: Periodontitis is a local inflammatory process mediating destruction of periodontal tissues triggered by bacterial insult. However, this disease is also characterized by systemic inflammatory host responses that may contribute, in part, to the recently reported higher risk for cardiovascular disease (CVD) among patients with periodontitis. Moderate elevation of C-reactive protein (CRP) has been found to be a predictor of increased risk for CVD. Elevated CRP levels in periodontal patients have been reported by several groups. In this study, we examined whether CRP plasma levels are increased in periodontitis and if there is a relation to severity of periodontal disease. Methods: CRP serum levels were assessed using reagen Immulite C-Reactive Protein ® / Immulite ® 1000 high-sensitivity CRP as a solid-phase, chemiluminescent immunometric assay in 100 subjects which diagnosed cardiovascular disease with chronic periodontitis. Periodontal Disease Index (PDI) were measured by clinical attachment loss, probing depths, and gingiva recession at six selection teeth : 16, 21, 24, 36, 41,44 known as Ramfjord teeth. Results: The measurement of Periodontal Disease Index (PDI) in 100 subjects with Cardiovascular Disease are Mild periodontitis (6,1%), Moderate periodontitis (70,4%), Severe periodontitis (23,5%) and only 2% with normal periodontal tissue. Increases in CRP levels were observed in these subjects. Subjects with high levels of clinical attachment loss (Severe periodontitis) had significantly higher mean of CRP levels (7,522 ± 0,3580 mg/L), moderate periodontitis are (5,284 ± 0,3138 mg/L) CRP levels and (2,017 ± 0,3656 mg/L) CRP levels for mild periodontitis Conclusions: The positive correlation between CRP and periodontal disease might be a possible underlying pathway in the association between periodontal disease which a chronic inflammation as one of risk factor for Cardiovascular Disease in these patients.